Differential Striatal Spine Pathology in Parkinson’s disease and Cocaine Addiction: A Key Role of Dopamine?
Identifieur interne : 000105 ( Main/Exploration ); précédent : 000104; suivant : 000106Differential Striatal Spine Pathology in Parkinson’s disease and Cocaine Addiction: A Key Role of Dopamine?
Auteurs : Rosa M. Villalba ; Yoland SmithSource :
- Neuroscience [ 0306-4522 ] ; 2013.
Abstract
In the striatum, the dendritic tree of the two main populations of projection neurons, called “Medium Spiny Neurons (MSNs)”, are covered with spines that receive glutamatergic inputs from the cerebral cortex and thalamus. In Parkinson’s disease (PD), striatal MSNs undergo an important loss of dendritic spines, whereas aberrant overgrowth of striatal spines occurs following chronic cocaine exposure. This review examines the possibility that opposite dopamine dysregulation is one of the key factors that underlies these structural changes. In PD, nigrostriatal dopamine degeneration results in a significant loss of dendritic spines in the dorsal striatum, while rodents chronically exposed to cocaine and other psychostimulants, display an increase in the density of “thin and immature” spines in the nucleus accumbens (NAc). In rodent models of PD, there is evidence that D2 dopamine receptor-containing MSNs are preferentially affected, while D1-positive cells are the main targets of increased spine density in models of addiction. However, such specificity remains to be established in primates. Although the link between the extent of striatal spine changes and the behavioral deficits associated with these disorders remains controversial, there is unequivocal evidence that glutamatergic synaptic transmission is significantly altered in both diseased conditions. Recent studies have suggested that opposite calcium-mediated regulation of the transcription factor myocyte enhancer factor 2 (MEF2) function induces these structural defects. In conclusion, there is strong evidence that dopamine is a major, but not the sole, regulator of striatal spine pathology in PD and addiction to psychostimulants. Further studies of the role of glutamate and other genes associated with spine plasticity in mediating these effects are warranted.
Url:
DOI: 10.1016/j.neuroscience.2013.07.011
PubMed: 23867772
PubMed Central: 3778087
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000258
- to stream Pmc, to step Curation: 000146
- to stream Pmc, to step Checkpoint: 000086
- to stream Ncbi, to step Merge: 000139
- to stream Ncbi, to step Curation: 000139
- to stream Ncbi, to step Checkpoint: 000139
- to stream Main, to step Merge: 000105
- to stream Main, to step Curation: 000105
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential Striatal Spine Pathology in Parkinson’s disease and Cocaine Addiction: A Key Role of Dopamine?</title>
<author><name sortKey="Villalba, Rosa M" sort="Villalba, Rosa M" uniqKey="Villalba R" first="Rosa M." last="Villalba">Rosa M. Villalba</name>
</author>
<author><name sortKey="Smith, Yoland" sort="Smith, Yoland" uniqKey="Smith Y" first="Yoland" last="Smith">Yoland Smith</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23867772</idno>
<idno type="pmc">3778087</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778087</idno>
<idno type="RBID">PMC:3778087</idno>
<idno type="doi">10.1016/j.neuroscience.2013.07.011</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000258</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000258</idno>
<idno type="wicri:Area/Pmc/Curation">000146</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000146</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000086</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000086</idno>
<idno type="wicri:Area/Ncbi/Merge">000139</idno>
<idno type="wicri:Area/Ncbi/Curation">000139</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000139</idno>
<idno type="wicri:doubleKey">0306-4522:2013:Villalba R:differential:striatal:spine</idno>
<idno type="wicri:Area/Main/Merge">000105</idno>
<idno type="wicri:Area/Main/Curation">000105</idno>
<idno type="wicri:Area/Main/Exploration">000105</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differential Striatal Spine Pathology in Parkinson’s disease and Cocaine Addiction: A Key Role of Dopamine?</title>
<author><name sortKey="Villalba, Rosa M" sort="Villalba, Rosa M" uniqKey="Villalba R" first="Rosa M." last="Villalba">Rosa M. Villalba</name>
</author>
<author><name sortKey="Smith, Yoland" sort="Smith, Yoland" uniqKey="Smith Y" first="Yoland" last="Smith">Yoland Smith</name>
</author>
</analytic>
<series><title level="j">Neuroscience</title>
<idno type="ISSN">0306-4522</idno>
<idno type="eISSN">1873-7544</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">In the striatum, the dendritic tree of the two main populations of projection neurons, called “Medium Spiny Neurons (MSNs)”, are covered with spines that receive glutamatergic inputs from the cerebral cortex and thalamus. In Parkinson’s disease (PD), striatal MSNs undergo an important loss of dendritic spines, whereas aberrant overgrowth of striatal spines occurs following chronic cocaine exposure. This review examines the possibility that opposite dopamine dysregulation is one of the key factors that underlies these structural changes. In PD, nigrostriatal dopamine degeneration results in a significant loss of dendritic spines in the dorsal striatum, while rodents chronically exposed to cocaine and other psychostimulants, display an increase in the density of “thin and immature” spines in the nucleus accumbens (NAc). In rodent models of PD, there is evidence that D2 dopamine receptor-containing MSNs are preferentially affected, while D1-positive cells are the main targets of increased spine density in models of addiction. However, such specificity remains to be established in primates. Although the link between the extent of striatal spine changes and the behavioral deficits associated with these disorders remains controversial, there is unequivocal evidence that glutamatergic synaptic transmission is significantly altered in both diseased conditions. Recent studies have suggested that opposite calcium-mediated regulation of the transcription factor myocyte enhancer factor 2 (MEF2) function induces these structural defects. In conclusion, there is strong evidence that dopamine is a major, but not the sole, regulator of striatal spine pathology in PD and addiction to psychostimulants. Further studies of the role of glutamate and other genes associated with spine plasticity in mediating these effects are warranted.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Smith, Yoland" sort="Smith, Yoland" uniqKey="Smith Y" first="Yoland" last="Smith">Yoland Smith</name>
<name sortKey="Villalba, Rosa M" sort="Villalba, Rosa M" uniqKey="Villalba R" first="Rosa M." last="Villalba">Rosa M. Villalba</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/DanceTherParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000105 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000105 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Psychologie |area= DanceTherParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3778087 |texte= Differential Striatal Spine Pathology in Parkinson’s disease and Cocaine Addiction: A Key Role of Dopamine? }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23867772" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a DanceTherParkinsonV1
This area was generated with Dilib version V0.6.35. |